Mr Nasrallah, in an address to mark the Ashoura holiday, said that Israeli Prime Minister Benjamin Netanyahu was working with the US government to undermine the nuclear deal with Iran and increase regional tensions.
Mr Trump has repeatedly condemned the Iran nuclear agreement, which placed limits on its research programme to halt alleged weapons development. It was welcomed internationally but opposed by Israel.
Mr Nasrallah said Israel had no idea “what awaits them if they go through with the idiocy of this war,” warning that “the zionist settlers will pay a heavy price.”
The Hezbollah leader, whose troops are fighting with the Syrian government, also called for the exposure and punishment “politically and economically” of those who have supported Isis.
Hezbollah’s involvement has been controversial in Lebanon, though it says fighting in Syria was needed to stop Isis’s spread to the country.