Campaigners fighting plans to axe maternity, casualty and children's services at St Helier Hospital in Sutton will take their protest to the doorstep of Health Minister and local MP Paul Burstow on Friday.
The delegation, including local people and hospital staff, will assemble outside Paul Burtow's office at noon on Friday in Gander Green Lane - little more than a mile from St Helier Hospital.
The hospital is set to lose its main services and a £219 million redevelopment scheme promised for the site would be scrapped.
London Health Emergency spokesman Geoff Martin said the people of Sutton were "sick and tired" of Mr Burstow's attempts to claim the plans were nothing to do with his department.
"He should resign as a minister and show that he is standing alongside his constituents and not just clinging on to the trappings of power and office," Mr Martin added.