London Met University vowed to "defend its reputation" and launch legal action against a decision to remove its licence to sponsor international students.
The government revoked the university's highly trusted status for sponsoring international students last week.
It claimed that it had found more than a quarter of students from a sample studying at the university did not have permission to stay in the country.
London Met said it would be contesting the decision after reading the UK Border Agency (UKBA) report in full.
"Working with its advisers, the university has conducted a thorough review of UKBA's 'evidence' and in the strongest possible terms challenges the outcome," a London Met spokesman said.
He added that there was "no evidence of systemic failings" at the university and that the evidence it had given to UKBA shows it was taking every reasonable measure to be comply with its rules.
The university was adamant it had conducted checks on its international students, specifically in relation to English language and their educational ability.
It was also clear that it checks that students are legally entitled to do study at the university.