London Metropolitan University has launched a legal challenge over the government's decision to revoke its sponsorship licence for overseas students.
The university's highly trusted status for sponsoring international students has been suspended while the UK Border Agency examines alleged failings.
More than 2,000 students have been left in limbo with only three months to find an alternative course or face deportation, officials have said.
London Met vice-chancellor Malcolm Gillies said the claims were "not particularly cogent.
"I would go so far as to say that UKBA has been rewriting its own guidelines on this issue and this is something which should cause concern to all universities," he said.
The government's handling of the case has been condemned by teaching unions and Labour.