The Ibrox side, who have turned in convincing home performances, have managed only draws in their two games on the road in the Third Division. Those came against Peterhead and Berwick, with the latter declared as "agony" and "unacceptable" by a furious Ally McCoist.
The Rangers midfielder Lewis MacLeod - who's signed a new long-term deal, along with Lee Wallace, Barrie Mckay, Robbie Crawford - is expected to keep his place against the Black and Golds.
The 18-year-old is hopeful of a more accomplished all-round performance from the Light Blues at the sell-out 2,500 capacity Galabank.
McCoist will be without two first-choice stars for the trip south to Dumfriesshire. Andy Little has a suspected stress fracture to his foot and the Greek full-back Anestis Argyriou is suffering with a hamstring strain.
Annan, who have spent £500,000 on a high-tech plastic pitch, were admitted to the senior ranks of Scottish football only four years ago.
Their chairman Henry McClelland described the fixture, which will see French and German TV reporters in attendance, as "by far the biggest game in the club's history."