Protests by tens of thousands of Pakistanis descended into violence on Friday, with police firing tear gas and live ammunition in an attempt to subdue rioters who hurled rocks and set fire to buildings.
At the time of going to press 19 people were reported dead and dozens injured.
Tens of thousands took to the streets to denounce the US-made film that has angered many Muslims around the world.
The government had declared a national holiday and declared a "day of love for the prophet" but there was little peaceful about the protests.
Thousands of protesters gathered in Peshawar and Multan, where they burned US flags and set tyres alight.
Police in Lahore used tear gas to disperse the crowds.
In Peshawar a mob set ransacked two cinemas and set them on fire, five people were killed and dozens others wounded by police bullets, tear gas and stones.
And in Islamabad police fired tear gas and live rounds into the air while other officers baton-charged protesters to keep around 5,000 marchers away from the diplomatic enclave.
At least five people were killed in Karachi, with armed protesters among a group of 15,000 firing on police. The crowd also burned two cinemas and a bank.
Demonstrators in Rawalpindi pelted cars and police with stones and burned down a toll booth.
In India, police clamped a day-long curfew on Srinagar and fired tear gas to disperse a group of women marching under the banner of Islamist women's group Dukhtaran-e-Millat chanting "Down with the US."
Thousands of people participated in protests across Kashmir.
In Iraq, about 3,000 protesters joined a march in Basra set up by Shi'ite groups.
And hundreds of Indonesians burnt a US flag outside its consulate in Medan.
Meanwhile in Surabaya protesters chanted "crush America, crush France" outside the French consulate and scuffled with police in riot gear.
About 3,000 Muslims marched on the US embassy in Malaysia, burning a US flag topped with the Star of David.
In the Sri Lankan capital Colombo about 2,000 Muslims burned effigies of President Barack Obama and US flags at a protest after Friday prayers.
And in Bangladesh over 2,000 people marched through the streets of Dhaka.
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