Cuba's Foreign Minister Bruno Rodriguez Parrilla told the UN general assembly on Monday that the US is keeping Cuba on its list of states that sponsor terrorism merely in order to justify its economic blockade of the socialist island.
Mr Rodriguez said the list's purpose "is to fabricate pretexts to increase the persecution of Cuba's financial transactions and justify the blockade policy which has caused incalculable human and economic damage."
He said Cuba remains ready to normalise relations with the US and criticised Washington's 50-year embargo.
Other Latin American officials at the UN emphasised the region's rise against imperial and US domination.
Cuba, Venezuela, Bolivia, Ecuador, Argentina, Uruguay and Brazil all have left-of-centre governments.
"The domination that the imperial powers and their multinationals have imposed on our development is being overcome," said Venezuelan ambassador Jorge Valero.
US State Department spokesman William Ostick refused to respond.