Cruz, ranked the world's fourth best featherweight by the WBO, said: "I've been fighting for more than 24 years and as I continue my ascendant career I want to be true to myself.
"I want to try to be the best role model I can be for kids who might look into boxing as a sport and a professional career.
"I have and will always be a proud Puerto Rican. I have always been and always will be a proud, gay man."