The news is a blow for Brendan Rodgers as he prepares his side for the visit of star-studded Russian outfit Anzhi Makhachkala.
Striker Samuel Eto’o and midfielders Jucilei and Mbark Boussoufa will pose the main threats for the Group A leaders in a match the Reds can ill-afford to lose.
Elsewhere Newcastle will start Cheick Tiote in their Group D match with Club Bruges.
The midfielder is set to serve a three-match Premier League ban after seeing red against Sunderland and Toon chief Alan Pardew confirmed he will start, along with youngsters Shane Ferguson and Sammy Ameobi.
Finally in Group J Tottenham will look to bounce back from Saturday’s defeat to Chelsea with a strong showing in Slovenia against NK Maribor.