Gatland is back in charge after working on preparatory business ahead of leading next summer’s British and Irish Lions tour to Australia.
In his absence Wales lost their opening autumn Tests against Argentina and Samoa, dropping to eighth place in the International Rugby Board world rankings as a result.
Switches from the 26-19 Samoa loss last Friday see starts for centre Jonathan Davies, fly-half Rhys Priestland, hooker Matthew Rees, lock Luke Charteris and skipper Sam Warburton.
And Gatland revealed the determination within the Dragons’ camp to succeed.
“Those supporters who have been with us over the last 18 months know, just as we do, that we are a better side than we have displayed so far, and we will be looking to show that on Saturday,” he said.