Teachers at the Mediacity academy in Manchester have voted to go on strike after bosses annouced 13 staff were to be sacked.
Parent company Oasis, which runs a chain of academies across Britain, made the annoucement on Tuesday.
Students showed solidarity with their embattled teachers by staging a protest outside the school.
Teachers' union NUT north west regional secretary Avis Gilmore said: "NUT members have shown how angry and frustrated they are with the way recent redundancies have been handled by voting Yes to strike action.
"Oasis have pushed through a redundancy process which should have taken months into less than five weeks. They have not consulted properly with either the staff or the trade unions.
"NUT, along with NASUWT, met with Oasis bosses on Wednesday and put the members views forward. We are awaiting a response from them."
The unions have given Oasis until November 17 to respond.
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