The Pool One encounter at Murrayfield gives the hosts an opportunity to avenge last weekend’s 19-9 defeat in Paris and they will also seek to score their first try in the competition.
Head coach Michael Bradley has made eight changes, including a return for fit-again centre Cairns.
Cairns’s fellow centre Ben Atiga also returns from injury along with Fijian back-row forward Netani Talei and Georgian number eight Dimitri Basilaia, who is on the bench.
Bradley said: “All of these players are straining at the leash, are desperate to get a win for Edinburgh and to put in a performance worthy of reselection.”