One of the strongest opponents of the controversial Health and Social Care Bill, the Royal College of General Practitioners, has written to David Cameron offering to re-enter talks on the issue.
But RCGP chairwoman Dr Clare Gerada said the body had in no way diluted its opposition to the legislation.
The letter was written more than a week ago but "nothing much has changed," she told BBC radio.
"What else are we supposed to do? We have tried everything."
She said: "Nothing has changed. The Royal College of GPs are still asking for withdrawal of this Bill.
"The Bill is so complicated, with hundreds and hundreds of amendments, that I challenge anybody to make sense of it.
"No organisation that represents health professionals or those working in the NHS want it.
"Let's stop this Bill and then let's work with the government to stabilise the NHS and to find a way through this."
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