Manchester United v Athletic Bilbao preview: Alex Ferguson's men eye history in cauldron of San Mames

During the phenomenal success of the Alex Ferguson era the Old Trafford outfit has very few firsts left to accomplish.

But despite the club's successes, on the previous two occasions United have lost a European first leg at home they have suffered defeat in the second leg too.

Having lost 3-2 at Old Trafford to an impressive-looking Bilbao, United face a difficult battle as they must score twice in front of the notoriously vocal San Mames crowd.

The challenge ahead is one that winger Ashley Young is relishing.

"It is unusual that we find ourselves in this position but there is a great team spirit here and everyone is full of confidence," said the former Aston Villa man.

"Our form in general makes us believe we can score wherever we play.

"Our attacking play has been fantastic of late and we believe we can score the two goals we need."

On the two occasions they have attempted a comeback away from Old Trafford, against Bayern Munich in 2001 and AC Milan four years later, they have lost the away leg as well.

And though Bilbao may not be in the same weight class as United's previous conquerors, the likes of towering target man Fernando Llorente and tricky forward Iker Munian will look to exploit any lack of concentration in the Red Devils' defence.

Young added: "Bilbao were an impressive team last week. They were a very attacking team, had a good team shape and at times we found them hard to break down.

"But I am sure if we are on our game 100 per cent we can go there and get the win we need."

Anderson, Nani and Phil Jones were all absent from United's flight to Spain, with the former rumoured to be out for the season with a hamstring injury.

The absence of Nani - who suffered bruising in Sunday's meeting with West Brom - is also a blow, though Antonio Valencia is back in the squad for the first time since the Ajax clash four weeks ago.

Also included is teenager Paul Pogba, despite question marks hanging over his future amid a reported offer from Italian giants Juventus.